Alléger les traitements des personnes séropositives,
c’est aujourd’hui possible.

 
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Cette perspective prometteuse, nous la devons au protocole ICCARRE initié en 2002 par le Dr Jacques Leibowitch, père de la trithérapie en France et clinicien de renommée internationale. Avec son équipe de l’hôpital Raymond Poincaré de Garches, il a montré que, même pris 4 jours sur 7 (et parfois moins), les antirétroviraux restent efficaces.

En 2016, l’essai 4D mené par l’Agence nationale de recherches sur le sida et les hépatites (ANRS), avec 100 patients volontaires, est venu confirmer la possibilité de passer à 4 jours de traitement par semaine au lieu de 7. Une nouvelle étude baptisée QUATUOR, et étendue à 640 patients débutera à la fin de l’année 2017.

Depuis plusieurs années, le Dr Leibowitch et l'association Les Amis d'ICCARRE se mobilisent pour que ces résultats conduisent à l’élaboration de nouvelles recommandations officielles de prescription et suscitent un changement des pratiques médicales.

Puisque HIV le veut bien, prendre moins d’antiviraux est un vrai progrès pour les patients.

Ce site propose d'informer patients, médecins, familles de patients, et citoyens sur les perspectives libératrices d'ICCARRE.

"Aux nombreuses personnes qui n’ont toujours pas accès aux trithérapies dans le monde.
À la mémoire des personnes décédées du sida faute de traitement efficace"

ICCARRE: FIGHTING THE OVER-MEDICATION OF HIV/AIDS PATIENTS

By 2020, France should be the first country to adopt a HIV/AIDS treatment plan that improves patients’ lives by reducing their medication from 365 to just 156 days a year in complete safety and in line with the ethical concept of Primum non nocere.

The fight begins…

In 2003, Dr Jacques Leibowitch and his associates at the Raymond Poincaré University Hospital in the Parisian suburb of Garches set out to prove that HIV/AIDS patients were over-medicated to the point that many stopped taking their medicine. 

They gave their research project the name ICCARRE, which has nothing to do with the Greek legend of the boy who flew too close to the sun, as Jacques Leibowitch is keen to point out. 

ICCARRE stands for Intermittents en Cycles Courts, les Antirétroviraux Restent Efficaces. In English, this phrase translates as ‘taken in short cycles, anti-retrovirals remain effective.’. 

The ICCARRE programme is largely unknown outside French medical circles and almost completely unknown to a wider public whose taxes fund this over-medication of HIV/AIDS patients.

The ICCARRE trials…

The ICCARRE team staged two clinical trials involving 48 and then 94 volunteer HIV/AIDS patients taking the standard ‘triple cocktail’ treatments seven days a week, reducing their treatment plan to just four days a week. 

The trials were 100% successful, proving that the patients had been over-medicated. As a bonus, the physical and mental quality of life of these patients improved dramatically once freed from the effects of their over-medication. 

In addition to these astonishing results, ten couples of differing HIV status with the HIV Positive partner on the 4-Day Plan conceived naturally and produced fourteen HIV-free babies. The HIV-free partners remained free of HIV contamination. 

Beakthrough…

In 2014, the French National Agency for AIDS/HIV Research (ANRS) reacted to the ICCARRE findings by initiating its own official trial, ANRS 162 4D, with 100 patients whose HIV plasma levels had been below the detection level for the previous year.

Presented at the 21st International AIDS Conference in South Africa in July 2016,  the results of the official French trials showed a 100% success rate in the cases of the 96 patients who had strictly adhered to the trial rules. 

The three ICCARRE and ARNS trials equated to 700 years of what Dr Leibowitch calls “interrupted treatment” without any failures and the ARNS has now scheduled a major QUATUOR trial aimed at obtaining government approval of the 4-Day Plan.

63 public hospitals will recruit a total of 640 patients who will be prescribed the ICCARRE 4-Day Plan for 96 weeks. A random selection of these volunteers will continue on the old 7-Day Plan. 

The benefits to society as a whole…

As well as improving the quality of life of HIV-AIDS patients, the ICCARRE 4-Day Plan will vastly reduce the cost to taxpayers of the current over-medication of HIV-AIDS patients.  

After you read this, you can help, wherever you are in the World, by spreading the news of this breakthough and asking your politicians when they plan to follow the French lead in the war on HIV/AIDS. 

ICCARRE

Paris, December 1st 2017